Mapping the anatomy of HD: a whole-brain history
Though many scientists have focused on damage to a part of the brain called the striatum as a source of HD symptoms, this is a narrow picture of what changes in the brain during HD. A new book provides a summary of many research techniques over a hundred years that have led to a more […]
Thiol-disulfide Oxidoreductases TRX1 and TMX3 Decrease Neuronal Atrophy…
Thiol-disulfide Oxidoreductases TRX1 and TMX3 Decrease Neuronal Atrophy in a Lentiviral Mouse Model of Huntington’s Disease Below is an abstract from a scientific report by Jonathan Fox, Zhen Lu and Lorraine Barrows. The full report is available here at PLOS Currents. ABSTRACT Huntington’s disease (HD) is caused by a trinucleotide CAG repeat in the […]
Huntington’s Research Sheds Light on Proteins’ Shift to Fibrous Solids
On Huntingtonsdiseasenews.com Ana Pampolna reports that recent research has shed light on how some proteins are converted into liquid droplets before becoming toxic fibrous solids that are involved in neurodegenerative diseases and other genetic disorders. The study entitled “RNA Controls PolyQ Protein Phase Transitions” was published in Molecular Cell by researchers from Dartmouth College, New Hampshire, and Princeton […]
Huntington’s Patients Often Also Suffer from Psychiatric Disorders
According to the findings of a recent study published in The American Journal of Psychiatry psychiatric manifestations develop more often than previously thought during Huntington’s disease prodrome. Moreover, it appears that symptoms increase with disease severity. Early features of Huntington’s disease can include mood swings, personality changes, fidgety movements, irritability and altered behavior, although these are […]
Story of search for Huntington’s cure wins science writing prize
Australian author and journalist Christine Kenneally has won The Bragg UNSW Press Prize for Science Writing for her article The Past May Not Make You Feel Better, about the search for a cure for Huntington’s disease. President of the Business Council of Australia, Catherine Livingstone, announced the winner of the $7000 prize at a ceremony on […]
Liftoff: First humans treated with gene silencing drugs for HD!
Originally published on HD Buzz on October 19, 2015 (By Dr Jeff Carroll on October 22, 2015, Edited by Dr Tamara Maiuri ) Today brings news that the first Huntington’s Disease patients have been successfully dosed with gene silencing drugs targeting the HD gene. These brave volunteers are the first HD patients to ever be […]