Category: Research

Could a new “jaw-dropping” breakthrough help treat Huntington’s Disease?

Recent days have seen a torrent of news stories about a new technology, called CRISPR, which has been described as having potential application in Huntington’s disease. Is this new technique as cool as it sounds? Possibly — but, as always, the truth is more complicated than the headlines suggest. The HD gene, and silencing it…
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The link between sleep disturbance and Huntingtons Disease

A review published in the journal Nature and Science of Sleep explores the links between sleep disturbance and neurodegeneration in diseases such as Huntington’s disease (HD). The authors state that sleep difficulties might not only be a symptom of the underlying neurodegeneration but also a contributing factor driving the disease. The review, “Chronic sleep disturbance and…
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IBM Researchers’ new approach could result in a breakthrough in Huntington’s treatment

Disruption in brain dynamics could underlie the pathophysiology of Huntington’s disease In 2011, IBM neuroscientists unveiled the Neural Tissue Simulator, a computer program that could simulate the way neurons talk to each other in the brain. A follow-up study by the same authors published earlier this year provides a potential new strategy for researchers studying the…
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Light shed on molecular mechanisms of Huntington’s

News-medical.net have reported that researchers at the University of Pittsburgh School of Medicine have shown that the core of the protein clumps found in the brains of people with Huntington’s disease have a distinctive structure, a finding that could shed light on the molecular mechanisms underlying the neurodegenerative disorder. The findings were published this week…
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Harnessing the power of viruses to treat Huntington’s disease

Researchers design a virus to more effectively deliver gene-silencing drugs throughout the brain New therapies for disorders like Huntington’s disease are on the way, but getting the drugs to enter brain cells can be a major challenge. A group of scientists has redesigned and tested a harmless virus that can efficiently deliver a ‘gene silencing’…
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Looking Past the Spin: Results from a Clinical Trial of Cysteamine

In early December, Raptor Pharmaceuticals released clinical trial results evaluating a drug called cysteamine in Huntington’s disease. News headlines about this trial are heavy on media spin, and so HDBuzz is here to break down what these new results really mean for the Huntington’s community. Clinical Trials and Pomegranates? Though it might not be obvious…
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huntingtons disease trial

A recycled drug gives us new insight in to HD

Researchers have found a connection between HD and an energy-regulating protein called PPAR-delta. Giving PPAR-delta a boost with an existing drug was protective in HD cells and mice, but we’ll likely need to research and test it further before it can go to the HD clinic. Repurposing therapies Sometimes a promising new drug proves to…
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Aspirin Component Shows Promise In Treating Alzheimer’s, Parkinson’s And Huntington’s Disease

On techtimes.com Rina Marie Doctor reports that researchers from the Boyce Thompson Institute and John Hopkins University found that aspirin component, salicylic acid, may help enhance treatments for neurological diseases such as Alzheimer’s, Parkinson’s and Huntington’s disease. Aside from these common uses of aspirin, the researchers of the new study wanted to find out if…
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Thiol-disulfide Oxidoreductases TRX1 and TMX3 Decrease Neuronal Atrophy…

Thiol-disulfide Oxidoreductases TRX1 and TMX3 Decrease Neuronal Atrophy in a Lentiviral Mouse Model of Huntington’s Disease Below is an abstract from a scientific report by Jonathan Fox, Zhen Lu and Lorraine Barrows. The full report is available here at PLOS Currents.   ABSTRACT Huntington’s disease (HD) is caused by a trinucleotide CAG repeat in the…
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