Category: Research

Looking Past the Spin: Results from a Clinical Trial of Cysteamine

In early December, Raptor Pharmaceuticals released clinical trial results evaluating a drug called cysteamine in Huntington’s disease. News headlines about this trial are heavy on media spin, and so HDBuzz is here to break down what these new results really mean for the Huntington’s community. Clinical Trials and Pomegranates? Though it might not be obvious…
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huntingtons disease trial

A recycled drug gives us new insight in to HD

Researchers have found a connection between HD and an energy-regulating protein called PPAR-delta. Giving PPAR-delta a boost with an existing drug was protective in HD cells and mice, but we’ll likely need to research and test it further before it can go to the HD clinic. Repurposing therapies Sometimes a promising new drug proves to…
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Aspirin Component Shows Promise In Treating Alzheimer’s, Parkinson’s And Huntington’s Disease

On techtimes.com Rina Marie Doctor reports that researchers from the Boyce Thompson Institute and John Hopkins University found that aspirin component, salicylic acid, may help enhance treatments for neurological diseases such as Alzheimer’s, Parkinson’s and Huntington’s disease. Aside from these common uses of aspirin, the researchers of the new study wanted to find out if…
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Thiol-disulfide Oxidoreductases TRX1 and TMX3 Decrease Neuronal Atrophy…

Thiol-disulfide Oxidoreductases TRX1 and TMX3 Decrease Neuronal Atrophy in a Lentiviral Mouse Model of Huntington’s Disease Below is an abstract from a scientific report by Jonathan Fox, Zhen Lu and Lorraine Barrows. The full report is available here at PLOS Currents.   ABSTRACT Huntington’s disease (HD) is caused by a trinucleotide CAG repeat in the…
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Huntington’s Research Sheds Light on Proteins’ Shift to Fibrous Solids

On Huntingtonsdiseasenews.com Ana Pampolna reports that recent research has shed light on how some proteins are converted into liquid droplets before becoming toxic fibrous solids that are involved in neurodegenerative diseases and other genetic disorders. The study entitled “RNA Controls PolyQ Protein Phase Transitions” was published in Molecular Cell by researchers from Dartmouth College, New Hampshire, and Princeton…
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