Huntington’s Research Sheds Light on Proteins’ Shift to Fibrous Solids

On Ana Pampolna reports that recent research has shed light on how some proteins are converted into liquid droplets before becoming toxic fibrous solids that are involved in neurodegenerative diseases and other genetic disorders. The study entitled “RNA Controls PolyQ Protein Phase Transitions” was published in Molecular Cell by researchers from Dartmouth College, New Hampshire, and Princeton University, New Jersey, USA.

Neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s and amyotrophic lateral sclerosis (ALS) have been known to develop from the loss of specific type of neurons, which is strictly associated with accumulation and deposition of particular protein aggregates.  These diseases show a similar profile of progressive neuronal death, nervous system deterioration, and cognitive impairment.

You can read Ana’s full report here.